Hepato-renal Effects of Cefotaxime in Albino Rats

Objective: The present study was carried out to evaluate the adverse effects of cefotaxime at two different doses on some biochemical parameters in albino rats. Histopathological changes in liver and kidney induced by cefotaxime were also investigated. Methods: Thirty rats were randomly divided into 3 equal groups; the first group was received distilled water and kept as a control. The second group was received cefotaxime (90 mg/kg b. wt), while the third group was received cefotaxime (180 mg/kg b. wt). Cefotaxime at different doses were injected intramuscularly (IM) twice daily at 12 h intervals for 7 consecutive days. Results: The obtained results showed that, cefotaxime produced significant elevation in creatinine, urea, sodium, potassium, calcium concentrations and decrease concentrations of both glucose and total protein in the serum of treated rats. Also, cefotaxime caused an elevation in some biochemical parameters as (Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), total bilirubin, Cholesterol, Triglycerides and Low density lipoprotein-cholesterol (LDL-chol) and decrease in albumin, High density lipoprotein-cholesterol (HDL-chol) concentrations in serum of treated rats. Histopathological alterations were observed in liver and kidney. Conclusions: It could be concluded that administration of cefotaxime induced some adverse effects on biochemical parameters as well as histopathological changes in liver and kidney.